Synthesis and Preclinical Studies of [61Cu]-N-(2-hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical
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Synthesis and Preclinical Studies of [61Cu]-N-(2-Hydroxyacetophenone)glycinate as a Possible PET Radiopharmaceutical
Cu]-N-(2-hydroxyacetophenone)glycinate ([Cu]NHAG) was prepared using in house-made NHAG ligand and [Cu]CuCl2 produced via the Zn(p,x)Cu (180μA proton irradiation, 22MeV, 3.2h) and purified by a ion chromatography method. [Cu]NHAG radiochemical purity was >98% and >99.9% by RTLC and HPLC methods respectively after purification by SPE. [Cu]NHAG was administered into normal and tumor bearing mice ...
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[61Cu]diacetyl-bis(N4-methylthiosemicarbazone) ([61Cu] ATSM) was prepared using in house-made diacetyl-bis(N4-methylthiosemicarbazone) (ATSM) ligand and [61Cu]CuCl2 produced via the natZn(p, x)61Cu (180 muA proton irradiation, 22 MeV, 3.2 h) and purified by a ion chromatography method. [61Cu]ATSM radiochemical purity was >98 %, as shown by HPLC and RTLC methods. [61Cu]ATSM was administered into...
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1. to determine whether difference in birth body mass influenced growth performance in pipistrellus kuhlii we studied a total of 12 captive-born neonates. bats were assigned to two body mass groups: light birth body mass (lbw: 0.89 ± 0.05, n=8) and heavy birth body mass (hbw: 1.35 ± 0.08, n=4). heavier body mass at birth was associated with rapid postnatal growth (body mass and forearm length) ...
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ژورنال
عنوان ژورنال: Scientia Pharmaceutica
سال: 2008
ISSN: 0036-8709
DOI: 10.3797/scipharm.0808-13